High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide

Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease (AD). We describe the engineering of cognate Anticalins as...

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Detalles Bibliográficos
Autores principales: Rauth, Sabine, Hinz, Dominik, Börger, Michael, Uhrig, Markus, Mayhaus, Manuel, Riemenschneider, Matthias, Skerra, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888463/
https://www.ncbi.nlm.nih.gov/pubmed/27029347
http://dx.doi.org/10.1042/BCJ20160114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888463/
https://www.ncbi.nlm.nih.gov/pubmed/27029347
http://dx.doi.org/10.1042/BCJ20160114

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