Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix

The mechanisms by which JAK2 is activated by the prevalent pseudokinase (JH2) V617F mutation in blood cancers remain elusive. Via structure-guided mutagenesis and transcriptional and functional assays, we identify a community of residues from the JH2 helix αC, SH2-JH2 linker and JH1 kinase domain th...

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Detalles Bibliográficos
Autores principales: Leroy, Emilie, Dusa, Alexandra, Colau, Didier, Motamedi, Amir, Cahu, Xavier, Mouton, Céline, Huang, Lily J., Shiau, Andrew K., Constantinescu, Stefan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888464/
https://www.ncbi.nlm.nih.gov/pubmed/27029346
http://dx.doi.org/10.1042/BCJ20160085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888464/
https://www.ncbi.nlm.nih.gov/pubmed/27029346
http://dx.doi.org/10.1042/BCJ20160085

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