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Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix

The mechanisms by which JAK2 is activated by the prevalent pseudokinase (JH2) V617F mutation in blood cancers remain elusive. Via structure-guided mutagenesis and transcriptional and functional assays, we identify a community of residues from the JH2 helix αC, SH2-JH2 linker and JH1 kinase domain th...

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Detalles Bibliográficos
Autores principales:	Leroy, Emilie, Dusa, Alexandra, Colau, Didier, Motamedi, Amir, Cahu, Xavier, Mouton, Céline, Huang, Lily J., Shiau, Andrew K., Constantinescu, Stefan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888464/ https://www.ncbi.nlm.nih.gov/pubmed/27029346 http://dx.doi.org/10.1042/BCJ20160085

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