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Reduction of cytosolic phospholipase A(2)α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal multifactorial neurodegenerative disease characterized by selective death of motor neurons in the cortex, brainstem, and spinal cord. Cytosolic phospholipase A(2) alpha (cPLA(2)α) upregulation and activation in the spinal cord of patients wi...

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Detalles Bibliográficos
Autores principales: Solomonov, Yulia, Hadad, Nurit, Levy, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888471/
https://www.ncbi.nlm.nih.gov/pubmed/27250836
http://dx.doi.org/10.1186/s12974-016-0602-y