Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels

BACKGROUND: Myocardial infarction (MI) is a major cause of heart failure. The carboxypeptidase cathepsin A is a novel target in the treatment of cardiac failure. We aim to show that recently developed inhibitors of the protease cathepsin A attenuate post-MI heart failure. METHODS: Mice were subjecte...

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Detalles Bibliográficos
Autores principales: Petrera, Agnese, Gassenhuber, Johann, Ruf, Sven, Gunasekaran, Deepika, Esser, Jennifer, Shahinian, Jasmin Hasmik, Hübschle, Thomas, Rütten, Hartmut, Sadowski, Thorsten, Schilling, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888645/
https://www.ncbi.nlm.nih.gov/pubmed/27246731
http://dx.doi.org/10.1186/s12967-016-0907-8

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