Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post‐translational modification: prospective placebo‐controlled clinical studies

Biochemical experiments, animal models, and observational studies in humans all support a role of dipeptidyl peptidase 4 (DPP4) in the N‐terminal truncation of CXCL10, which results in the generation of an antagonist form of the chemokine that limits T‐cell and NK cell migration. Motivated by the ab...

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Detalles Bibliográficos
Autores principales: Decalf, Jérémie, Tarbell, Kristin V, Casrouge, Armanda, Price, Jeffrey D, Linder, Grace, Mottez, Estelle, Sultanik, Philippe, Mallet, Vincent, Pol, Stanislas, Duffy, Darragh, Albert, Matthew L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888857/
https://www.ncbi.nlm.nih.gov/pubmed/27137491
http://dx.doi.org/10.15252/emmm.201506145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888857/
https://www.ncbi.nlm.nih.gov/pubmed/27137491
http://dx.doi.org/10.15252/emmm.201506145

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