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Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1

The gp41 membrane-proximal external region (MPER) is a target for broadly neutralizing antibody responses against human immunodeficiency virus type 1 (HIV-1). However, replication-defective virus vaccines currently under evaluation in clinical trials do not efficiently elicit MPER-specific antibodie...

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Detalles Bibliográficos
Autores principales: Boehme, Karl W., Ikizler, Mine', Iskarpatyoti, Jason A., Wetzel, J. Denise, Willis, Jordan, Crowe, James E., LaBranche, Celia C., Montefiori, David C., Wilson, Gregory J., Dermody, Terence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888892/
https://www.ncbi.nlm.nih.gov/pubmed/27303748
http://dx.doi.org/10.1128/mSphere.00086-16