Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease

The cerebral deposition of Aβ(42), a neurotoxic proteolytic derivate of amyloid precursor protein (APP), is a central event in Alzheimer’s disease (AD)(Amyloid hypothesis). Given the key role of APP-Aβ metabolism in AD pathogenesis, we selected 29 genes involved in APP processing, Aβ degradation and...

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Detalles Bibliográficos
Autores principales: Sassi, Celeste, Ridge, Perry G., Nalls, Michael A., Gibbs, Raphael, Ding, Jinhui, Lupton, Michelle K., Troakes, Claire, Lunnon, Katie, Al-Sarraj, Safa, Brown, Kristelle S., Medway, Christopher, Lord, Jenny, Turton, James, Morgan, Kevin, Powell, John F., Kauwe, John S., Cruchaga, Carlos, Bras, Jose, Goate, Alison M., Singleton, Andrew B., Guerreiro, Rita, Hardy, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889076/
https://www.ncbi.nlm.nih.gov/pubmed/27249223
http://dx.doi.org/10.1371/journal.pone.0150079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889076/
https://www.ncbi.nlm.nih.gov/pubmed/27249223
http://dx.doi.org/10.1371/journal.pone.0150079

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