Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca(2+) Sensitivity and Na(+)/H(+) Exchange and Mediates Protection by Ischemic Preconditioning

BACKGROUND: Sphingosine‐1‐phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia–reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine‐1‐phosphate receptor 1 (S1P(1)) in vivo is unknown. METHODS AND RESULTS: Cardiomyocyte‐restricted del...

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Detalles Bibliográficos
Autores principales: Keul, Petra, van Borren, Marcel M. G. J., Ghanem, Alexander, Müller, Frank Ulrich, Baartscheer, Antonius, Verkerk, Arie O., Stümpel, Frank, Schulte, Jan Sebastian, Hamdani, Nazha, Linke, Wolfgang A., van Loenen, Pieter, Matus, Marek, Schmitz, Wilhelm, Stypmann, Jörg, Tiemann, Klaus, Ravesloot, Jan‐Hindrik, Alewijnse, Astrid E., Hermann, Sven, Spijkers, Léon J. A., Hiller, Karl‐Heinz, Herr, Deron, Heusch, Gerd, Schäfers, Michael, Peters, Stephan L. M., Chun, Jerold, Levkau, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889204/
https://www.ncbi.nlm.nih.gov/pubmed/27207969
http://dx.doi.org/10.1161/JAHA.116.003393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889204/
https://www.ncbi.nlm.nih.gov/pubmed/27207969
http://dx.doi.org/10.1161/JAHA.116.003393

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