PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

PrimPol is a DNA damage tolerant polymerase displaying both translesion synthesis (TLS) and (re)-priming properties. This led us to study the consequences of a PrimPol deficiency in tolerating mutagenic lesions induced by members of the APOBEC/AID family of cytosine deaminases. Interestingly, during...

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Detalles Bibliográficos
Autores principales: Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Pritchard, Colin, Blomberg, Olga S., Huijbers, Ivo J., van den Berk, Paul C.M., Jacobs, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889928/
https://www.ncbi.nlm.nih.gov/pubmed/26926109
http://dx.doi.org/10.1093/nar/gkw123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889928/
https://www.ncbi.nlm.nih.gov/pubmed/26926109
http://dx.doi.org/10.1093/nar/gkw123

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