Selection of DNA nanoparticles with preferential binding to aggregated protein target

High affinity and specificity are considered essential for affinity reagents and molecularly-targeted therapeutics, such as monoclonal antibodies. However, life's own molecular and cellular machinery consists of lower affinity, highly multivalent interactions that are metastable, but easily rev...

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Detalles Bibliográficos
Autores principales: Ruff, Laura E., Sapre, Ajay A., Plaut, Justin S., De Maere, Elisabeth, Mortier, Charlotte, Nguyen, Valerie, Separa, Kevin, Vandenbogaerde, Sofie, Vandewalle, Laura, Esener, Sadik C., Messmer, Bradley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889931/
https://www.ncbi.nlm.nih.gov/pubmed/26969734
http://dx.doi.org/10.1093/nar/gkw136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889931/
https://www.ncbi.nlm.nih.gov/pubmed/26969734
http://dx.doi.org/10.1093/nar/gkw136

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