Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ

Benzo[a]pyrene (BP) is a well-known and frequently encountered carcinogen which generates a bulky DNA adduct (+)-trans-10S-BP-N(2)-dG (BP-dG) in cells. DNA polymerase kappa (polκ) is the only known Y-family polymerase that bypasses BP-dG accurately and thus protects cells from genotoxic BP. Here, we...

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Detalles Bibliográficos
Autores principales: Jha, Vikash, Bian, Chuanbing, Xing, Guangxin, Ling, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889944/
https://www.ncbi.nlm.nih.gov/pubmed/27034468
http://dx.doi.org/10.1093/nar/gkw204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889944/
https://www.ncbi.nlm.nih.gov/pubmed/27034468
http://dx.doi.org/10.1093/nar/gkw204

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