Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition

Sequence-specific binding to DNA is crucial for targeting transcription factor-DNA complexes to modulate gene expression. The heterocyclic diamidine, DB2277, specifically recognizes a single G•C base pair in the minor groove of mixed base pair sequences of the type AAAGTTT. NMR spectroscopy reveals...

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Detalles Bibliográficos
Autores principales: Harika, Narinder K., Paul, Ananya, Stroeva, Ekaterina, Chai, Yun, Boykin, David W., Germann, Markus W., Wilson, W. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889958/
https://www.ncbi.nlm.nih.gov/pubmed/27131382
http://dx.doi.org/10.1093/nar/gkw353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889958/
https://www.ncbi.nlm.nih.gov/pubmed/27131382
http://dx.doi.org/10.1093/nar/gkw353

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