A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer

Although human LINE-1 (L1) elements are actively mobilized in many cancers, a role for somatic L1 retrotransposition in tumor initiation has not been conclusively demonstrated. Here, we identify a novel somatic L1 insertion in the APC tumor suppressor gene that provided us with a unique opportunity...

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Detalles Bibliográficos
Autores principales: Scott, Emma C., Gardner, Eugene J., Masood, Ashiq, Chuang, Nelson T., Vertino, Paula M., Devine, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889970/
https://www.ncbi.nlm.nih.gov/pubmed/27197217
http://dx.doi.org/10.1101/gr.201814.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889970/
https://www.ncbi.nlm.nih.gov/pubmed/27197217
http://dx.doi.org/10.1101/gr.201814.115

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