A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets

A continuing challenge in the analysis of massively large sequencing data sets is quantifying and interpreting non-neutrally evolving mutations. Here, we describe a flexible and robust approach based on the site frequency spectrum to estimate the fraction of deleterious and adaptive variants from la...

Descripción completa

Detalles Bibliográficos
Autores principales: Moon, Sunjin, Akey, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889975/
https://www.ncbi.nlm.nih.gov/pubmed/27197222
http://dx.doi.org/10.1101/gr.203059.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889975/
https://www.ncbi.nlm.nih.gov/pubmed/27197222
http://dx.doi.org/10.1101/gr.203059.115

Ejemplares similares