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A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets
A continuing challenge in the analysis of massively large sequencing data sets is quantifying and interpreting non-neutrally evolving mutations. Here, we describe a flexible and robust approach based on the site frequency spectrum to estimate the fraction of deleterious and adaptive variants from la...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889975/ https://www.ncbi.nlm.nih.gov/pubmed/27197222 http://dx.doi.org/10.1101/gr.203059.115 |