Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology

Demonstrating a candidate drug’s interaction with its target protein in live cells is of pivotal relevance to the successful outcome of the drug discovery process. Although thymidylate synthase (hTS) is an important anticancer target protein, the efficacy of the few anti-hTS drugs currently used in...

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Detalles Bibliográficos
Autores principales: Ponterini, Glauco, Martello, Andrea, Pavesi, Giorgia, Lauriola, Angela, Luciani, Rosaria, Santucci, Matteo, Pelà, Michela, Gozzi, Gaia, Pacifico, Salvatore, Guerrini, Remo, Marverti, Gaetano, Costi, Maria Paola, D’Arca, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890114/
https://www.ncbi.nlm.nih.gov/pubmed/27250901
http://dx.doi.org/10.1038/srep27198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890114/
https://www.ncbi.nlm.nih.gov/pubmed/27250901
http://dx.doi.org/10.1038/srep27198

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