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The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling

Insulin facilitates glucose uptake into cells by translocating the glucose transporter GLUT4 towards the cell surface through a pathway along an insulin receptor (IR)/IR substrate 1 (IRS-1)/phosphatidylinositol 3 kinase (PI3K)/3-phosphoinositide-dependent protein kinase-1 (PDK1)/Akt axis. The newly...

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Detalles Bibliográficos
Autores principales: Nishizaki, Tomoyuki, Gotoh, Akinobu, Shimizu, Tadashi, Tanaka, Akito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890120/
https://www.ncbi.nlm.nih.gov/pubmed/27251941
http://dx.doi.org/10.1038/srep27267