Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30–40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise referred to as ‘ovarian carcinomas', which frequently...

Descripción completa

Detalles Bibliográficos
Autores principales: Bartlett, Thomas E., Chindera, Kantaraja, McDermott, Jacqueline, Breeze, Charles E., Cooke, William R., Jones, Allison, Reisel, Daniel, Karegodar, Smita T., Arora, Rupali, Beck, Stephan, Menon, Usha, Dubeau, Louis, Widschwendter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890182/
https://www.ncbi.nlm.nih.gov/pubmed/27216078
http://dx.doi.org/10.1038/ncomms11620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890182/
https://www.ncbi.nlm.nih.gov/pubmed/27216078
http://dx.doi.org/10.1038/ncomms11620

Ejemplares similares