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Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30–40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise referred to as ‘ovarian carcinomas', which frequently...

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Detalles Bibliográficos
Autores principales:	Bartlett, Thomas E., Chindera, Kantaraja, McDermott, Jacqueline, Breeze, Charles E., Cooke, William R., Jones, Allison, Reisel, Daniel, Karegodar, Smita T., Arora, Rupali, Beck, Stephan, Menon, Usha, Dubeau, Louis, Widschwendter, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890182/ https://www.ncbi.nlm.nih.gov/pubmed/27216078 http://dx.doi.org/10.1038/ncomms11620

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