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Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling
The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes...
Autores principales: | Katoh, Takayuki, Wohlgemuth, Ingo, Nagano, Masanobu, Rodnina, Marina V., Suga, Hiroaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890201/ https://www.ncbi.nlm.nih.gov/pubmed/27216360 http://dx.doi.org/10.1038/ncomms11657 |
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