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Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish

Upstream open reading frames (uORFs) are ubiquitous repressive genetic elements in vertebrate mRNAs. While much is known about the regulation of individual genes by their uORFs, the range of uORF-mediated translational repression in vertebrate genomes is largely unexplored. Moreover, it is unclear w...

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Detalles Bibliográficos
Autores principales: Chew, Guo-Liang, Pauli, Andrea, Schier, Alexander F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890304/
https://www.ncbi.nlm.nih.gov/pubmed/27216465
http://dx.doi.org/10.1038/ncomms11663