Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains

We previously reported that the levels of α-syn oligomers, which play pivotal pathogenic roles in age-related Parkinson's disease (PD) and dementia with Lewy bodies, increase heterogeneously in the aging brain. Here, we show that exogenous α-syn incubated with brain extracts from older cynomolg...

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Detalles Bibliográficos
Autores principales: Chen, Min, Yang, Weiwei, Li, Xin, Li, Xuran, Wang, Peng, Yue, Feng, Yang, Hui, Chan, Piu, Yu, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890980/
https://www.ncbi.nlm.nih.gov/pubmed/27032368
http://dx.doi.org/10.18632/oncotarget.6445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890980/
https://www.ncbi.nlm.nih.gov/pubmed/27032368
http://dx.doi.org/10.18632/oncotarget.6445

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