Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens

Aromatic amines (AAs) are chemicals of industrial, pharmacological and environmental relevance. Certain AAs, such as 4-aminobiphenyl (4-ABP), are human carcinogens that require enzymatic metabolic activation to reactive chemicals to form genotoxic DNA adducts. Arylamine N-acetyltransferases (NAT) ar...

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Detalles Bibliográficos
Autores principales: Duval, Romain, Xu, Ximing, Bui, Linh-Chi, Mathieu, Cécile, Petit, Emile, Cariou, Kevin, Dodd, Robert H., Dupret, Jean-Marie, Rodrigues-Lima, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890997/
https://www.ncbi.nlm.nih.gov/pubmed/26840026
http://dx.doi.org/10.18632/oncotarget.7086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890997/
https://www.ncbi.nlm.nih.gov/pubmed/26840026
http://dx.doi.org/10.18632/oncotarget.7086

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