Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis

High polo-like kinase 1 (PLK1) expression has been linked to poor outcome in neuroblastoma (NB), indicating that it represents a relevant therapeutic target in this malignancy. Here, we identify a synergistic induction of apoptosis by the PLK1 inhibitor BI 2536 and vinca alkaloids in NB cells. Syner...

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Detalles Bibliográficos
Autores principales: Czaplinski, Sebastian, Hugle, Manuela, Stiehl, Valerie, Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890998/
https://www.ncbi.nlm.nih.gov/pubmed/26046302
http://dx.doi.org/10.18632/oncotarget.3901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890998/
https://www.ncbi.nlm.nih.gov/pubmed/26046302
http://dx.doi.org/10.18632/oncotarget.3901

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