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Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis

High polo-like kinase 1 (PLK1) expression has been linked to poor outcome in neuroblastoma (NB), indicating that it represents a relevant therapeutic target in this malignancy. Here, we identify a synergistic induction of apoptosis by the PLK1 inhibitor BI 2536 and vinca alkaloids in NB cells. Syner...

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Detalles Bibliográficos
Autores principales:	Czaplinski, Sebastian, Hugle, Manuela, Stiehl, Valerie, Fulda, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890998/ https://www.ncbi.nlm.nih.gov/pubmed/26046302 http://dx.doi.org/10.18632/oncotarget.3901

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