Cargando…

Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis

High polo-like kinase 1 (PLK1) expression has been linked to poor outcome in neuroblastoma (NB), indicating that it represents a relevant therapeutic target in this malignancy. Here, we identify a synergistic induction of apoptosis by the PLK1 inhibitor BI 2536 and vinca alkaloids in NB cells. Syner...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czaplinski, Sebastian, Hugle, Manuela, Stiehl, Valerie, Fulda, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890998/ https://www.ncbi.nlm.nih.gov/pubmed/26046302 http://dx.doi.org/10.18632/oncotarget.3901

Ejemplares similares

Vinca Alkaloids
por: Moudi, Maryam, et al.
Publicado: (2013)

Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells
por: Czaplinski, Sebastian, et al.
Publicado: (2015)

In vitro antagonism between cisplatin and vinca alkaloids.
por: Lee, K., et al.
Publicado: (1989)

New semisynthetic vinca alkaloids: chemical, biochemical and cellular studies
por: Orosz, F, et al.
Publicado: (1999)

Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
por: Lee, Chun-Ting, et al.
Publicado: (2015)

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings
por: Keglevich, András, et al.
Publicado: (2018)

Resistance to anti-tubulin agents: From vinca alkaloids to epothilones
por: Krause, Werner
Publicado: (2019)

A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas
por: Gatz, Susanne A., et al.
Publicado: (2019)

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
por: Wei, Xin, et al.
Publicado: (2017)

End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo
por: Berges, Raphael, et al.
Publicado: (2014)

Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)
por: Bailey, Anders W., et al.
Publicado: (2018)

Metabolites of Vinca Alkaloid Vinblastine: Tubulin Binding and Activation of Nausea-Associated Receptors
por: Chagas, Caroline Manto, et al.
Publicado: (2019)

Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth
por: Chilamakuri, Rameswari, et al.
Publicado: (2022)

Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development
por: Kruczynski, A, et al.
Publicado: (2002)

Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation
por: Szaflarski, Witold, et al.
Publicado: (2016)

Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience
por: Batra, Akshee, et al.
Publicado: (2021)

The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis
por: Stander, Emily Amor, et al.
Publicado: (2022)

Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids()()
por: Sharbeen, G., et al.
Publicado: (2016)

Metabolomics analysis reveals both plant variety and choice of hormone treatment modulate vinca alkaloid production in Catharanthus roseus
por: Fraser, Valerie N., et al.
Publicado: (2020)

Polo-like kinase in trypanosomes: an odd member out of the Polo family
por: Kurasawa, Yasuhiro, et al.
Publicado: (2020)

Comparative effects of vinca alkaloids (VCR, VDS) and epipodophyllotoxin (VP16) on murine myeloblastic leukaemia.
por: Yamashita, Y., et al.
Publicado: (1987)

Negative-Pressure Cavitation Extraction of Four Main Vinca Alkaloids from Catharanthus roseus Leaves
por: Mu, Fansong, et al.
Publicado: (2012)

Putting a bit into the polo-box domain of polo-like kinase 1
por: Park, Jung-Eun, et al.
Publicado: (2015)

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP
por: Streckmann, Fiona, et al.
Publicado: (2018)

Identifying Genes Involved in Alkaloid Biosynthesis in Vinca minor through Transcriptomics and Gene Co-Expression Analysis
por: Stander, Emily Amor, et al.
Publicado: (2020)

Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti
por: De Vita, Daniela, et al.
Publicado: (2023)

Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines
por: WeiΔ, Lilly Magdalena, et al.
Publicado: (2017)

The balance of Polo-like kinase 1 in tumorigenesis
por: Lu, Lin-Yu, et al.
Publicado: (2009)

The CINs of Polo-Like Kinase 1 in Cancer
por: Cunningham, Chelsea E., et al.
Publicado: (2020)

Therapeutic inhibition of polo‐like kinases in anaplastic thyroid cancer
por: Lin, Shu‐Fu, et al.
Publicado: (2021)

Polo-like kinase 1 is involved in apoptosis, invasion, and metastasis of pancreatic ductal adenocarcinoma
por: Mao, Yonghuan, et al.
Publicado: (2020)

Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents
por: Wang, Richard C., et al.
Publicado: (2017)

Polo-like kinase 1 inhibition in NSCLC: mechanism of action and emerging predictive biomarkers
por: Stratmann, Jan A, et al.
Publicado: (2019)

Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity
por: Zhang, Dangquan, et al.
Publicado: (2020)

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)
por: Liu-Sullivan, Nancy, et al.
Publicado: (2011)

Development of a Cell Suspension Culture System for Promoting Alkaloid and Vinca Alkaloid Biosynthesis Using Endophytic Fungi Isolated from Local Catharanthus roseus
por: Linh, Tran My, et al.
Publicado: (2021)

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway
por: Tian, Xiangdong, et al.
Publicado: (2018)

Polo-like kinase-1 in DNA damage response
por: Hyun, Sun-Yi, et al.
Publicado: (2014)

Polo-like kinase 1 as target for cancer therapy
por: Weiß, Lily, et al.
Publicado: (2012)

Playing POLO-like kinase in NRAS mutant melanoma
por: Chen, Hsin-Yi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_els9gp4kclnrls1tg9krjqnbee