CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression

Our previous studies showed that MYB is required for proliferation of, and confers protection against apoptosis on, estrogen receptor-positive (ER(+ve)) breast cancer cells, which are almost invariably also MYB(+ve). We have also shown that MYB expression in ER(+ve) breast cancer cells is regulated...

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Detalles Bibliográficos
Autores principales: Mitra, Partha, Yang, Ren-Ming, Sutton, James, Ramsay, Robert G., Gonda, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891027/
https://www.ncbi.nlm.nih.gov/pubmed/26812885
http://dx.doi.org/10.18632/oncotarget.6997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891027/
https://www.ncbi.nlm.nih.gov/pubmed/26812885
http://dx.doi.org/10.18632/oncotarget.6997

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