In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors

Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry. We found a positive correlation between nuclear GL...

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Detalles Bibliográficos
Autores principales: Benvenuto, Monica, Masuelli, Laura, De Smaele, Enrico, Fantini, Massimo, Mattera, Rosanna, Cucchi, Danilo, Bonanno, Elena, Di Stefano, Enrica, Frajese, Giovanni Vanni, Orlandi, Augusto, Screpanti, Isabella, Gulino, Alberto, Modesti, Andrea, Bei, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891038/
https://www.ncbi.nlm.nih.gov/pubmed/26843616
http://dx.doi.org/10.18632/oncotarget.7062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891038/
https://www.ncbi.nlm.nih.gov/pubmed/26843616
http://dx.doi.org/10.18632/oncotarget.7062

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