miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells

miR-143 and miR-145 are downregulated in colon cancer. Here, we tested the effect of restoring these miRNAs on sensitization to cetuximab in mutant KRAS (HCT116 and SW480) and wild-type KRAS (SW48) colon cancer cells. We evaluated cetuximab-mediated antibody-dependent cellular cytotoxicity (ADCC) an...

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Detalles Bibliográficos
Autores principales: Gomes, Sofia E., Simões, André E. S., Pereira, Diane M., Castro, Rui E., Rodrigues, Cecília M. P., Borralho, Pedro M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891046/
https://www.ncbi.nlm.nih.gov/pubmed/26824186
http://dx.doi.org/10.18632/oncotarget.7010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891046/
https://www.ncbi.nlm.nih.gov/pubmed/26824186
http://dx.doi.org/10.18632/oncotarget.7010

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