Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptormediated apoptosis

PURPOSE: DNA repair defects due to detrimental BRCA2-mutations confer increased susceptibility towards DNA interstrand-crosslinking (ICL) agents and define patient subpopulations for individualized genotype-based cancer therapy. However, due to the side effects of these drugs, there is a need to ide...

Descripción completa

Detalles Bibliográficos
Autores principales: De Toni, Enrico N., Ziesch, Andreas, Rizzani, Antonia, Török, Helga-Paula, Hocke, Sandra, Lü, Shuai, Wang, Shao-Chun, Hucl, Tomas, Göke, Burkhard, Bruns, Christiane, Gallmeier, Eike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891053/
https://www.ncbi.nlm.nih.gov/pubmed/26843614
http://dx.doi.org/10.18632/oncotarget.7053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891053/
https://www.ncbi.nlm.nih.gov/pubmed/26843614
http://dx.doi.org/10.18632/oncotarget.7053

Ejemplares similares