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Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptormediated apoptosis

PURPOSE: DNA repair defects due to detrimental BRCA2-mutations confer increased susceptibility towards DNA interstrand-crosslinking (ICL) agents and define patient subpopulations for individualized genotype-based cancer therapy. However, due to the side effects of these drugs, there is a need to ide...

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Detalles Bibliográficos
Autores principales:	De Toni, Enrico N., Ziesch, Andreas, Rizzani, Antonia, Török, Helga-Paula, Hocke, Sandra, Lü, Shuai, Wang, Shao-Chun, Hucl, Tomas, Göke, Burkhard, Bruns, Christiane, Gallmeier, Eike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891053/ https://www.ncbi.nlm.nih.gov/pubmed/26843614 http://dx.doi.org/10.18632/oncotarget.7053

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