Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling

Tumor initiating cells (TICs) serve as the root of tumor growth. After identifying TICs in spontaneous breast tumors of the MMTV-Wnt1 mouse model, we confirmed the specific expression and activation of Yes-associated protein 1 (Yap1) within TICs. To investigate the role of Yap1 in the self-renewal o...

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Detalles Bibliográficos
Autores principales: Sun, Jian-Guo, Chen, Xie-Wan, Zhang, Lu-Ping, Wang, Jiang, Diehn, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891077/
https://www.ncbi.nlm.nih.gov/pubmed/26695440
http://dx.doi.org/10.18632/oncotarget.6655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891077/
https://www.ncbi.nlm.nih.gov/pubmed/26695440
http://dx.doi.org/10.18632/oncotarget.6655

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