Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways

Zoledronate is a standard treatment for preventing skeletal complications of osteoporosis and some types of cancer associated with bone metastases, but we little know whether the effect of zoledronate on metastasis of osteosarcoma. Here, we investigated the inhibitory effects of zoledronate on cell...

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Detalles Bibliográficos
Autores principales: Cheng, Hsin-Lin, Lin, Chiao-Wen, Yang, Jia-Sin, Hsieh, Ming-Ju, Yang, Shun-Fa, Lu, Ko-Hsiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891081/
https://www.ncbi.nlm.nih.gov/pubmed/26848867
http://dx.doi.org/10.18632/oncotarget.7138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891081/
https://www.ncbi.nlm.nih.gov/pubmed/26848867
http://dx.doi.org/10.18632/oncotarget.7138

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