Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1

Biliary tract cancer (BTC) is a highly malignant cancer. BTC exhibits a low response rate to cisplatin (CDDP) treatment, and therefore, an understanding of the mechanism of CDDP resistance is urgently needed. Here, we show that BTC cells develop CDDP resistance due, in part, to upregulation of myelo...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Qiwei, Zhan, Ming, Chen, Wei, Zhao, Benpeng, Yang, Kai, Yang, Jie, Yi, Jing, Huang, Qihong, Mohan, Man, Hou, Zhaoyuan, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891119/
https://www.ncbi.nlm.nih.gov/pubmed/26848531
http://dx.doi.org/10.18632/oncotarget.7171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891119/
https://www.ncbi.nlm.nih.gov/pubmed/26848531
http://dx.doi.org/10.18632/oncotarget.7171

Ejemplares similares