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Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation

Differential subcellular localization of EBP50 leads to its controversial role in cancer biology either as a tumor suppressor when it resides at the membrane periphery, or a tumor facilitator at the nucleus. However, the mechanism behind nuclear localization of EBP50 remains unclear. A RNA interfere...

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Detalles Bibliográficos
Autores principales: Lim, HooiCheng, Jou, Tzuu-Shuh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891120/
https://www.ncbi.nlm.nih.gov/pubmed/26862730
http://dx.doi.org/10.18632/oncotarget.7184