Cargando…

Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

Statins (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors) are well-established agents to treat hyperlipidemic states. Experimental and epidemiological evidence further implies an anticancer effect of these substances. This study investigates the mechanism underlying human lung c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walther, Udo, Emmrich, Kristin, Ramer, Robert, Mittag, Nadine, Hinz, Burkhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891124/ https://www.ncbi.nlm.nih.gov/pubmed/26863638 http://dx.doi.org/10.18632/oncotarget.7213

Ejemplares similares

Combined COX-2/PPARγ Expression as Independent Negative Prognosticator for Vulvar Cancer Patients
por: Ansorge, Nadine, et al.
Publicado: (2021)

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
por: Capelli, Davide, et al.
Publicado: (2023)

The Role of PPAR-γ and Its Interaction with COX-2 in Pancreatic Cancer
por: Eibl, Guido
Publicado: (2008)

PPARγ and Apoptosis in Cancer
por: Elrod, Heath A., et al.
Publicado: (2008)

Repurposing of substances with lactone moiety for the treatment of γ-Hydroxybutyric acid and γ-Butyrolactone intoxication through modulating paraoxonase and PPARγ
por: Fateh, Sepand Tehrani, et al.
Publicado: (2022)

Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers
por: Shao, Wanting, et al.
Publicado: (2020)

The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
por: Huizar, Isham, et al.
Publicado: (2013)

New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
por: Kamizela, Angelika, et al.
Publicado: (2019)

Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway
por: Muskal, Steven M., et al.
Publicado: (2016)

Interleukin-1β Induces Tissue Factor Expression in A549 Cells via EGFR-Dependent and -Independent Mechanisms
por: Mechelke, Tobias, et al.
Publicado: (2021)

Cannabinoids as anticancer drugs: current status of preclinical research
por: Hinz, Burkhard, et al.
Publicado: (2022)

Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases
por: Ramer, Robert, et al.
Publicado: (2022)

Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis
por: Chan, David Y. L., et al.
Publicado: (2007)

COX-2 and PPARγ expression are potential markers of recurrence risk in mammary duct carcinoma in-situ
por: Kulkarni, Swati, et al.
Publicado: (2008)

Morphine enhances LPS-induced macrophage apoptosis through a PPARγ-dependent mechanism
por: Lin, Mingying, et al.
Publicado: (2021)

The Critical Role of PPARγ in Human Malignant Melanoma
por: Freudlsperger, Christian, et al.
Publicado: (2008)

Inhibitory effect of lovastatin on human lung cancer cell proliferation by regulating the ERK1/2 and COX-2 pathways
por: Liu, Sha, et al.
Publicado: (2022)

Modulation of the Endocannabinoid System as a Potential Anticancer Strategy
por: Ramer, Robert, et al.
Publicado: (2019)

The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies
por: Ramer, Robert, et al.
Publicado: (2021)

Effect of γ-lactones and γ-lactams compounds on Streptococcus mutans biofilms
por: Sordi, Mariane Beatriz, et al.
Publicado: (2018)

PPARγ, PTEN, and the Fight against Cancer
por: Teresi, Rosemary E., et al.
Publicado: (2008)

Nuclear peroxisome proliferator activated receptor-gamma (PPARγ) as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of abuse
por: Ciccocioppo, Roberto, et al.
Publicado: (2020)

Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF-κB/COX-2/PPAR-γ activities
por: Wang, Zhimin, et al.
Publicado: (2019)

Structural basis for the biosynthesis of lovastatin
por: Wang, Jialiang, et al.
Publicado: (2021)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Decisive role of P42/44 mitogen-activated protein kinase in Δ(9)-tetrahydrocannabinol-induced migration of human mesenchymal stem cells
por: Lüder, Ellen, et al.
Publicado: (2017)

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance
por: Martirosyan, Anna, et al.
Publicado: (2010)

PPARγ-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma
por: Chaffer, Christine L, et al.
Publicado: (2006)

PPARγ Expression Is Diminished in Macrophages of Recurrent Miscarriage Placentas
por: Kolben, Theresa Maria, et al.
Publicado: (2018)

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator
por: Xie, Xinni, et al.
Publicado: (2017)

Microbial Production and Biomedical Applications of Lovastatin
por: Seenivasan, A., et al.
Publicado: (2008)

The role of lovastatin in the attenuation of COVID-19
por: Karampoor, Sajad, et al.
Publicado: (2021)

Effects of Lovastatin on Brain Cancer Cells
por: Amadasu, Efosa, et al.
Publicado: (2022)

Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin
por: Vree, Tom B., et al.
Publicado: (2003)

PPARγ, neuroinflammation, and disease
por: Mrak, Robert E, et al.
Publicado: (2004)

Nutraceuticals as Ligands of PPARγ
por: Penumetcha, Meera, et al.
Publicado: (2012)

PPARγ and Cognitive Performance
por: d’Angelo, Michele, et al.
Publicado: (2019)

Modelling neurofibromatosis type 1 tibial dysplasia and its treatment with lovastatin
por: Kolanczyk, Mateusz, et al.
Publicado: (2008)

α-linolenic acid inhibits human renal cell carcinoma cell proliferation through PPAR-γ activation and COX-2 inhibition
por: YANG, LIJUN, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mi7166r7p0un1a4kmkmc7vouce