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MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR

The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded chemokine receptor vGPCR acts as an oncogene in Kaposi's sarcomagenesis. Until now, the molecular mechanisms by which the vGPCR contributes to tumor development remain incompletely understood. Here, we show that the KSHV-vGPCR cont...

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Detalles Bibliográficos
Autores principales: Krause, Claudia J., Popp, Oliver, Thirunarayanan, Nanthakumar, Dittmar, Gunnar, Lipp, Martin, Müller, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891129/
https://www.ncbi.nlm.nih.gov/pubmed/26871287
http://dx.doi.org/10.18632/oncotarget.7248