A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent

Current tools for the inhibition of microRNA (miR) function are limited to modified antisense oligonucleotides, sponges and decoy RNA molecules and none have been used to understand miR function during development. CRISPR/Cas-mediated deletion of miR sequences within the genome requires multiple chr...

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Detalles Bibliográficos
Autores principales: Cao, H, Yu, W, Li, X, Wang, J, Gao, S, Holton, N E, Eliason, S, Sharp, T, Amendt, B A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article - Enabling Technologies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891277/
https://www.ncbi.nlm.nih.gov/pubmed/26934100
http://dx.doi.org/10.1038/gt.2016.22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891277/
https://www.ncbi.nlm.nih.gov/pubmed/26934100
http://dx.doi.org/10.1038/gt.2016.22

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