In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters

BACKGROUND AND OBJECTIVES: Lesinurad is a selective uric acid reabsorption inhibitor (SURI) under investigation for the treatment of gout. This study elucidated the interaction of lesinurad with major liver and kidney transporters in vitro and evaluated the drug–drug interactions (DDIs) of lesinurad...

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Detalles Bibliográficos
Autores principales: Shen, Zancong, Yeh, Li-Tain, Wallach, Kathleen, Zhu, Nanqun, Kerr, Brad, Gillen, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891385/
https://www.ncbi.nlm.nih.gov/pubmed/26951201
http://dx.doi.org/10.1007/s40261-016-0386-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891385/
https://www.ncbi.nlm.nih.gov/pubmed/26951201
http://dx.doi.org/10.1007/s40261-016-0386-y

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