Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice

Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα rearrangement between the Trav11 and Traj18 g...

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Detalles Bibliográficos
Autores principales: Zhang, Jingjing, Bedel, Romain, Krovi, S. Harsha, Tuttle, Kathryn D., Zhang, Bicheng, Gross, James, Gapin, Laurent, Matsuda, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891675/
https://www.ncbi.nlm.nih.gov/pubmed/27256918
http://dx.doi.org/10.1038/srep27375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891675/
https://www.ncbi.nlm.nih.gov/pubmed/27256918
http://dx.doi.org/10.1038/srep27375

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