A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer’s disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice

Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs memory and cognition. Targeting amyloid-β (Aβ) may be currently the most promising immunotherapeutic strategy for AD. In this study, a recombinant chimeric 6Aβ15-THc-C immunogen was formulated with alum adjuvant as a novel Aβ B-ce...

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Detalles Bibliográficos
Autores principales: Yu, Yun-Zhou, Liu, Si, Wang, Hai-Chao, Shi, Dan-Yang, Xu, Qing, Zhou, Xiao-Wei, Sun, Zhi-Wei, Huang, Pei-Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891678/
https://www.ncbi.nlm.nih.gov/pubmed/27255752
http://dx.doi.org/10.1038/srep27175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891678/
https://www.ncbi.nlm.nih.gov/pubmed/27255752
http://dx.doi.org/10.1038/srep27175

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