Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein

The pH of extracellular fluids is a basic property of the tissue microenvironment and is normally maintained at 7.40 ± 0.05 in humans. Many pathological circumstances, such as ischemia, inflammation, and tumorigenesis, result in the reduction of extracellular pH in the affected tissues. In this stud...

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Detalles Bibliográficos
Autores principales: Tao, Shi-Cong, Gao, You-Shui, Zhu, Hong-Yi, Yin, Jun-Hui, Chen, Yi-Xuan, Zhang, Yue-Lei, Guo, Shang-Chun, Zhang, Chang-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891712/
https://www.ncbi.nlm.nih.gov/pubmed/27256071
http://dx.doi.org/10.1038/srep26835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891712/
https://www.ncbi.nlm.nih.gov/pubmed/27256071
http://dx.doi.org/10.1038/srep26835

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