Nmnat1 protects neuronal function without altering phospho‐tau pathology in a mouse model of tauopathy

OBJECTIVE: The nicotinamide‐nucleotide adenylyltransferase protein Nmnat1 is a potent inhibitor of axonal degeneration in models of acute axonal injury. Hyperphosphorylation and aggregation of the microtubule‐associated protein Tau are associated with neurodegeneration in Alzheimer's Disease an...

Descripción completa

Detalles Bibliográficos
Autores principales: Musiek, Erik S., Xiong, David D., Patel, Tirth, Sasaki, Yo, Wang, Yinong, Bauer, Adam Q., Singh, Risham, Finn, Samantha L., Culver, Joseph P., Milbrandt, Jeffrey, Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891997/
https://www.ncbi.nlm.nih.gov/pubmed/27547771
http://dx.doi.org/10.1002/acn3.308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891997/
https://www.ncbi.nlm.nih.gov/pubmed/27547771
http://dx.doi.org/10.1002/acn3.308

Ejemplares similares