BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data

Summary: Runs of homozygosity (RoHs) are genomic stretches of a diploid genome that show identical alleles on both chromosomes. Longer RoHs are unlikely to have arisen by chance but are likely to denote autozygosity, whereby both copies of the genome descend from the same recent ancestor. Early tool...

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Detalles Bibliográficos
Autores principales: Narasimhan, Vagheesh, Danecek, Petr, Scally, Aylwyn, Xue, Yali, Tyler-Smith, Chris, Durbin, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892413/
https://www.ncbi.nlm.nih.gov/pubmed/26826718
http://dx.doi.org/10.1093/bioinformatics/btw044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892413/
https://www.ncbi.nlm.nih.gov/pubmed/26826718
http://dx.doi.org/10.1093/bioinformatics/btw044

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