Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation

The high circulating levels of histones found in various thrombotic diseases may compromise the anticoagulant barrier of endothelial cells. We determined how histones affect endothelial procoagulant tissue factor (TF) and anticoagulant thrombomodulin (TM). Surface antigens, soluble forms, and mRNA l...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ji Eun, Yoo, Hyun Ju, Gu, Ja Yoon, Kim, Hyun Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892514/
https://www.ncbi.nlm.nih.gov/pubmed/27258428
http://dx.doi.org/10.1371/journal.pone.0156763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892514/
https://www.ncbi.nlm.nih.gov/pubmed/27258428
http://dx.doi.org/10.1371/journal.pone.0156763

Ejemplares similares