CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development

The SLAM family receptors contribute to diverse aspects of lymphocyte biology and signal via the small adaptor molecule SAP. Mutations affecting SAP lead to X-linked lymphoproliferative syndrome Type 1, a severe immunodysregulation characterized by fulminant mononucleosis, dysgammaglobulinemia, and...

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Detalles Bibliográficos
Autores principales: Huang, Bonnie, Gomez-Rodriguez, Julio, Preite, Silvia, Garrett, Lisa J., Harper, Ursula L., Schwartzberg, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892526/
https://www.ncbi.nlm.nih.gov/pubmed/27258160
http://dx.doi.org/10.1371/journal.pone.0156072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892526/
https://www.ncbi.nlm.nih.gov/pubmed/27258160
http://dx.doi.org/10.1371/journal.pone.0156072

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