Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila

UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy, endocytosis and DNA damage repair, but how its loss contributes to colorectal cancer is poorly understood. Here, we show that UVRAG deficiency in Drosophila intestinal stem cells leads to uncontrolled prolif...

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Detalles Bibliográficos
Autores principales: Nagy, Péter, Kovács, Laura, Sándor, Gyöngyvér O., Juhász, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892661/
https://www.ncbi.nlm.nih.gov/pubmed/26921396
http://dx.doi.org/10.1242/dmm.023416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892661/
https://www.ncbi.nlm.nih.gov/pubmed/26921396
http://dx.doi.org/10.1242/dmm.023416

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