Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

Insulin receptor substrate-2-deficient (IRS2(−/−)) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play...

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Detalles Bibliográficos
Autores principales: Baquedano, Eva, Burgos-Ramos, Emma, Canelles, Sandra, González-Rodríguez, Agueda, Chowen, Julie A., Argente, Jesús, Barrios, Vicente, Valverde, Angela M., Frago, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892662/
https://www.ncbi.nlm.nih.gov/pubmed/27013528
http://dx.doi.org/10.1242/dmm.023515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892662/
https://www.ncbi.nlm.nih.gov/pubmed/27013528
http://dx.doi.org/10.1242/dmm.023515

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