Cargando…

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

Insulin receptor substrate-2-deficient (IRS2(−/−)) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baquedano, Eva, Burgos-Ramos, Emma, Canelles, Sandra, González-Rodríguez, Agueda, Chowen, Julie A., Argente, Jesús, Barrios, Vicente, Valverde, Angela M., Frago, Laura M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892662/ https://www.ncbi.nlm.nih.gov/pubmed/27013528 http://dx.doi.org/10.1242/dmm.023515

Ejemplares similares

Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism
por: Burgos-Ramos, Emma, et al.
Publicado: (2016)

Cerebral Insulin Bolus Revokes the Changes in Hepatic Lipid Metabolism Induced by Chronic Central Leptin Infusion
por: Barrios, Vicente, et al.
Publicado: (2021)

Chronic Central Leptin Infusion Promotes an Anti-Inflammatory Cytokine Profile Related to the Activation of Insulin Signaling in the Gastrocnemius of Male Rats
por: Barrios, Vicente, et al.
Publicado: (2022)

Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid
por: Frago, Laura M., et al.
Publicado: (2017)

Opposite Effects of Chronic Central Leptin Infusion on Activation of Insulin Signaling Pathways in Adipose Tissue and Liver Are Related to Changes in the Inflammatory Environment
por: Barrios, Vicente, et al.
Publicado: (2021)

Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis
por: Barrios, Vicente, et al.
Publicado: (2021)

Prenatal Stress Induces Long-Term Effects in Cell Turnover in the Hippocampus-Hypothalamus-Pituitary Axis in Adult Male Rats
por: Baquedano, Eva, et al.
Publicado: (2011)

Adipose Tissue Promotes a Serum Cytokine Profile Related to Lower Insulin Sensitivity after Chronic Central Leptin Infusion
por: Burgos-Ramos, Emma, et al.
Publicado: (2012)

Neuroprotective Actions of Ghrelin and Growth Hormone Secretagogues
por: Frago, Laura M., et al.
Publicado: (2011)

Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels
por: García-Cáceres, Cristina, et al.
Publicado: (2011)

Sex Differences in Metabolic Recuperation After Weight Loss in High Fat Diet-Induced Obese Mice
por: Guerra-Cantera, Santiago, et al.
Publicado: (2021)

Impact of Long-Term HFD Intake on the Peripheral and Central IGF System in Male and Female Mice
por: Guerra-Cantera, Santiago, et al.
Publicado: (2020)

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice
por: Vinaixa, María, et al.
Publicado: (2021)

The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice
por: Guerra-Cantera, Santiago, et al.
Publicado: (2023)

MON-LB083 The Dimorphic Effects of Short-Term Dietary Changes on the Central and Circulating IGF1 System in Rats
por: Guerra Cantera, Santiago, et al.
Publicado: (2019)

Changes in Lipid Metabolism Enzymes in Rat Epididymal Fat after Chronic Central Leptin Infusion Are Related to Alterations in Inflammation and Insulin Signaling
por: Casado, María E., et al.
Publicado: (2023)

Short-Term Diet Induced Changes in the Central and Circulating IGF Systems Are Sex Specific
por: Guerra-Cantera, Santiago, et al.
Publicado: (2020)

SAT-593 Sex-Specific Modifications in MicroRNAs Contained in Exosomes of Astrocytes in Response to Palmitic Acid
por: Chowen, Julie Ann, et al.
Publicado: (2020)

Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS)
por: Ferrer-Donato, Agueda, et al.
Publicado: (2021)

Fatty Acids Modify the MicroRNA Content of Exosomes Released by Hypothalamic Astrocytes and the Response of POMC Neurons to These Exosomes
por: Collado-Pérez, Roberto, et al.
Publicado: (2021)

Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations
por: Mastrangelo, A, et al.
Publicado: (2016)

Long Term Hippocampal and Cortical Changes Induced by Maternal Deprivation and Neonatal Leptin Treatment in Male and Female Rats
por: Mela, Virginia, et al.
Publicado: (2015)

Effects of Maternal Resveratrol Intake on the Metabolic Health of the Offspring
por: Ros, Purificación, et al.
Publicado: (2021)

Role of Non-Neuronal Cells in Body Weight and Appetite Control
por: Argente-Arizón, Pilar, et al.
Publicado: (2015)

Involvement of Astrocytes in Mediating the Central Effects of Ghrelin
por: Frago, Laura M., et al.
Publicado: (2017)

Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens
por: Argente-Arizón, Pilar, et al.
Publicado: (2016)

Ethnicity Strongly Influences Body Fat Distribution Determining Serum Adipokine Profile and Metabolic Derangement in Childhood Obesity
por: Martos-Moreno, Gabriel Á., et al.
Publicado: (2020)

Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?
por: Chowen, Julie A., et al.
Publicado: (2017)

LBODP109 Astrocytes Affect The Metabolism Of Proopiomelanocortin (pomc) Neurons Through The Release Of Exosomes That Are Modified In A Fatty Acid Specific Manner
por: Collado-Pérez, Roberto, et al.
Publicado: (2022)

Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone β-Subunit in Peripubertal Male Rats
por: Argente-Arizón, Pilar, et al.
Publicado: (2018)

Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats
por: Mela, Virginia, et al.
Publicado: (2016)

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent
por: Prentice, Leah M, et al.
Publicado: (2011)

Sex differences in adipose tissue: It is not only a question of quantity and distribution
por: Fuente-Martín, Esther, et al.
Publicado: (2013)

Sex Differences in Hypothalamic Changes and the Metabolic Response of TgAPP Mice to a High Fat Diet
por: Freire-Regatillo, Alejandra, et al.
Publicado: (2022)

Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes
por: Fuente-Martín, Esther, et al.
Publicado: (2016)

Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease
por: Barrios, Vicente, et al.
Publicado: (2021)

Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals
por: Freire-Regatillo, Alejandra, et al.
Publicado: (2017)

SUN-LB016 The Long Term Effects of Resveratrol Supplementation during Pregnancy and Lactation on Adipose Tissue Morphology in the Adult Offspring
por: Ros-Pérez, Purificación, et al.
Publicado: (2019)

Living without insulin: the role of leptin signaling in the hypothalamus
por: Fujikawa, Teppei, et al.
Publicado: (2015)

Global Changes in Lipid Profiles of Mouse Cortex, Hippocampus, and Hypothalamus Upon p53 Knockout
por: Lee, Sang Tak, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cbmgd7470qgcj2guve0168i7os