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CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) immune checkpoints are negative regulators of T-cell immune function. Inhibition of these targets, resulting in increased activation of the immune system, has led to new immunotherapies for melanoma, non–small cel...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Lippincott Williams & Wilkins
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892769/ https://www.ncbi.nlm.nih.gov/pubmed/26558876 http://dx.doi.org/10.1097/COC.0000000000000239 |